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In a 16-week randomized study of 30 obese men with functional hypogonadism who had responded poorly to lifestyle measures, liraglutide raised total testosterone by an average of 2.6 nmol/L and significantly increased LH and FSH a pattern suggesting the HPT axis itself recovered rather than testosterone simply being replaced (Jensterle et al., 2019, Endocrine Connections )

All these side effects can be seen with oral or transdermal methimazole or oral carbimazole, but GI side effects are typically less common (less than 5%) with transdermal application 10

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10.2147/ndt.S302443 64 JieZ.XiaH.ZhongS