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The net effect of the TZDs is a potentiation of the actions of insulin in liver, adipose tissue and skeletal muscle, increased peripheral glucose disposal and a decrease in glucose output by the liver

Beyond a certain threshold, higher doses don't produce additional benefits and may actually reduce effectiveness through receptor desensitization

In Phase 2 trials involving participants with type 2 diabetes, HbA1c improved by up to 2.2%, with 82% of participants reaching HbA1c levels at or below 6.5%

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