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Change history 04 July 2025 The original version of this article was revised: The family name of author Miryam Paola Alvarez-Flores has been corrected

This combination is more recovery-focused than hormone-focused

As shown in Figures 5CE, compared with the control group, methylglyoxal significantly reduced GLP-1R level, increased inflammatory factor (IL-1, TNF, IL-6, iNOS and COX2) levels, increased ROS content, and reduced antioxidant enzyme activities (SOD, CAT, GSH, GPx), while daphnetin-treated showed significant anti-inflammatory and antioxidant effects and increased GLP-1R expression

Note subjective factors like energy and sleep