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Lilly also has tirzepatide (Mounjaro), a dual GIP and GLP-1 RA, which is demonstrating significant efficacy in glucose control and weight loss and poses a considerable competitive threat

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Dose adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness to minimize the risk of hypoglycemia or hyperglycemia [see Warnings and Precautions (5.3)]

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