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Clinicians should also monitor nutritional risks associated with rapid weight loss, such as deficiencies in iron, folic acid, and B vitamins, to ensure the patient is pregnancy-ready rather than just weight-ready. Given that GLP-1RAs improving IVF outcomes remains limited, their appropriate positioning remains a metabolic optimization tool before ART rather than a standardized pretreatment regimen (48)

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For example, two phase III studies (6) were conducted with 806 test subjects over 26 weeks, followed by another 26-week extension