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Semaglutide (GLP-1 mono-agonist) typically delivers around 14.9% loss at 68 weeks in STEP 1, against roughly 22.5% for tirzepatide 15 mg in SURMOUNT-1 [4]

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In contrast, if you do not maintain healthy lifestyle changes and start taking a high-calorie diet or skipping exercise, you are more likely to regain the lost weight

FIGURE 3 Glutathione Peroxidase 1 Inhibits Apoptosis of Spiral Ganglion Neurons After Peroxynitrite Injury The role of GPX1 in regulating the peroxynitrite-induced apoptosis of cochlear SGNs was investigated by immunostaining and western blot