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Nature Medicine , 28(5), 898-910

The major findings are (1) Eighteen compounds were precisely identified in ZXGD with a LCMS/MS based chemical profiling method, neohesperidin and naringin have a potential in alleviating pulmonary vascular remodeling

In further embodiments, the auris formulation or composition contains a viscosity enhancing agent or viscosity modulating agent sufficient to provide a viscosity of between about 10 and 1,000,000 centipoise, between about 100 and 1,000,000 centipoise, between about 500 and 1,000,000 centipoise, between about 750 and 1,000,000 centipoise