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(6) Therapeutic efficacy is highly time sensitive, with optimal outcomes occurring prior to completion of the aging process and markedly reduced oxime responsiveness after the post-aging window

The daily limits for children are 1-3 Years: 300 mcg 4-8 Years: 400 mcg 9-13 Years: 600 mcg 14-18 Years: 800 mcg Also, the L-5-methyltetrahydrofolate (L-5-MTHF) supplement is safe for children

Disclosure of interest: miriam caterino: nothing to disclose E-Posters - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.06 - CARDIOEMBOLISM & HEART-BRAIN INTERACTIONS P2453 - ESOC25-2484 DETERMINANTS OF HIGH-SENSITIVITY TROPONIN ELEVATION IN PATIENTS WITH ISCHEMIC STROKE AND TRANSIENT ISCHEMIC ATTACK Anna Komarova 1 , Andrey Shavarov 1 , Natalia Krivosheeva 1 , Kirill Eroshkin 1 , Vladimir Zhuravlev 1 , Eugenia Astapovich 1 , Regina Ostrikova 1 1 Botkin hospital, Moscow, Russian Federation Background and Aims: The availability of high-sensitivity (hs) diagnostic assays requires a precise understanding the full spectrum of cardiac and non-cardiac diseases to interpret elevated cardiac troponin (hs-cTn) levels