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Following agonist binding, the GLP-1R is rapidly endocytosed, and whilst active G protein coupled receptors (GPCRs) can continue to generate intracellular signals within the endosomal compartment (Eichel and Zastrow, 2018), the availability of surface GLP-1Rs to extracellular ligand appears to be an important determinant of sustained insulinotropic efficacy in a pharmacological setting (Jones et al., 2018b)

New GLP-1 and multi-agonist medications are entering the market, potentially reducing supply pressure on existing drugs

Apply pressure and slowly push the needle into the chosen injection site

Nat Rev Endocrinol (2018) 14:285300