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Neurological: Numbness or tingling in the extremities (paresthesias), difficulty walking, balance problems, muscle weakness, vision problems, cognitive disorders (difficulty concentrating, memory loss), mood changes (depression, irritability)

Moreover, experiments in rat renal tubular (NRK-52E) cells showed the accumulation of fluorescently labelled polymyxins in both the ER and mitochondrial compartments 53

TB-500 operates primarily through actin dynamics: it binds G-actin monomers to regulate the monomeric actin pool, which is thought to influence cell migration in experimental wound models