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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

In fact, there was a 2022 case report presented a 22-year-old student who exhibited hyperpigmentation as the only symptom of B12 deficiency

Bright yellow urine may result from excessive vitamin B2 (riboflavin), but this is usually harmless and doesnt mean you need to stop taking the vitamins

Certain medications can interact with vitamin B12