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For patients with advanced liver disease, the decision to initiate tirzepatide should involve careful risk-benefit assessment and consultation with hepatology specialists when appropriate

The lower weight loss in diabetic populations likely reflects differences in baseline metabolic status rather than reduced drug efficacy

A useful protocol records storage temperature, reconstitution conditions, time in solution, freeze-thaw history, vial appearance, and any analytical checks performed before use

In 2024 the Food and Drug Administration added cardiovascular risk as a reason to be prescribed the GLP-1 drug Wegovy, grounded in results from a major trial that showed fewer heart attacks, strokes, and cardiovascular deaths in adults with obesity or overweight and established heart disease