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Dual receptor agonism approaches are also showing promise in phase 2 trials of MASH with both Tirzepatide (a dual GLP1/GIP agonist) and Survodutide (a dual GLP1/Glucagon receptor agonist) meeting their primary end-points of remitting steatohepatitis without worsening of fibrosis and improvement in fibrosis stage of 1 grade without worsening of steatohepatitis when compared with placebo [53, 54]

Additionally, the phenylalanine-rich region named crevasse in the inactive structure of the ghrelin receptor is absent in the motilin receptor (Shiimura et al., 2020

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Storage conditions: Store in dry places, at room temperature, in tightly closed containers