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When disorders of fatty acid -oxidation metabolism and abnormalities of branched-chain amino acid metabolism occur, characteristic alterations of one or more acyl carnitines occur

A recent review paper provides a great deal of detail about various pathways where cardiolipin plays a central role in driving pore formation in a variety of different pathogenic mechanisms ( Figure 7 illustrates schematically the steps that we propose take place over a long period of time, with cardiolipin initially protecting the ATPase pumps from deuterium, but ultimately, as the diseased state progresses, sequestering deuterium trapped in cardiolipin along with amyloid deposits

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