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GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists exert their primary gastrointestinal effects by slowing gastric emptying and reducing intestinal motility

One of the largest retrospective studies from Japan (70 NAMs and 123 non-NAM acral melanomas) reported low objective response rate of anti-PD-1 monotherapy: 21.1% in patients with acral melanoma and 8.6% in patients with NAM [108]