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Curr Neuropharmacol 2016;14(8):857-865

The incidence of hypoglycaemia in Muslim patients with type 2 diabetes treated with sitagliptin or a sulphonylurea during Ramadan: a randomised trial

however, new technologies like chemical modifications (e.g., cyclic peptides), nanoparticles, and specific absorption enhancers (like SNAC in Ozempic's oral version, Rybelsus) are making oral delivery possible for certain therapeutic peptides, like semaglutide (Wegovy/Ozempic), transforming them from injections to convenient tablets, though many supplements lack strong evidence