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The histomorphological changes in hepatotoxic liver enlargement without enzyme induction include fluid accumulation, fatty change in hepatocytes, inflammatory cell infiltration, fibrosis, and possibly granuloma formation (Glaister 1986
doi:10.1016/j.redox.2015.07.012 Shang F, Wang Z, Tan T (2008) High-cell-density cultivation for co-production of ergosterol and reduced glutathione by Saccharomyces cerevisiae
A variety of anticancer drugs based on these principles have been synthesized in efforts to improve their therapeutic indices and reverse tumor resistance
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