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Biomedicines 10:116 Kadhim HM, Kadhim YM, Fawzi HA, Abdul Khalik ZM, Jawad AM, Ghdira K (2025) Bioassay-guided isolation and active compounds identification of the antidiabetic fractions of Centaurea calcitrapa extract and the predicted interaction mechanism

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Additionally, plasma protein binding (e.g., with albumin, g-glycoprotein, etc.) can decrease placental transport, as only the unbound xenobiotic passes through the placental barrier, which can enhance placental transport by passive diffusion mechanisms

HDAC inhibitors are structurally classified into four major categories: hydroxamate, short-chain fatty acids (carboxylate), benzamide, and cyclic peptide [55]