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71 Glutamate is the main neurotransmitter in the central nervous system, and extracellular glutamate levels are maintained by the exchange of extracellular cysteine for intracellular glutamate
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There is evidence that the use of dipeptidyl peptidase-4 inhibitors (DPP-4) (gliptins) and/or glucagon-like peptide-1 (GLP-1) mimetics is associated with a higher rate of Parkinson's disease compared with the use of other oral antidiabetic drugs 2
The finding challenges long-held assumptions about how GLP-1 medicines work in the liver and could reshape how physicians treat metabolic liver disease
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