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The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)

The core mechanism lies in mimicking the naturally existing GHK-Cu complex in the human body, which can directly interact with cell DNA and regulate the expression of genes related to tissue repair, anti-inflammatory and antioxidant functions

The dose, indication, and treatment goals differ