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Severity typically correlates with dose and individual sensitivity rather than the compound itself being inherently dangerous

6.4.1 Regulatory restrictions on EED use 6.4.1.1 Chemical-specific regulations European Union and United States regulations restricting BPA use in food packaging applications have achieved substantial exposure reductions, with mean population exposure levels declining by 63% in affected regions (140)

0.5 mg/0.1 ml saline/each eye) in rats immediately produced moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc and faint presentation of the choroidal blood vessels, and these lesions rapidly progressed to the severe stage

Comment: Many commenters generally supported the proposed definition of bundled arrangement but were concerned with the inclusion of purchasing patterns and prior purchases in the proposed definition as examples of performance requirements, not only because of misalignment with MDRP, but commenters stated that these words create ambiguity because they are not defined in the proposed rule nor explained why they were included