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Following discovery of a sparse number of occurrences of progressive multifocal leukoencephalopathy (PML) in those taking a FAE, median duration of FAE therapy to PML symptom onset or appearance of first PML brain lesion was 31 months (range 6110), with median duration of lymphocytopenia to PML symptoms being 23 months (range 672)

[1] It was first used to treat diabetes in 1957, however, it received limited attention since it was less potent than other medications

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

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