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Menstrual changes during treatment may include longer or shorter cycles, heavier or lighter bleeding, or missed periods, typically related to the rate and magnitude of weight loss

This could be attributed to the fact that by not using the patches for 2 days in a week (about 30% less exposure to glutathione), the subjects in Cohort 2 did not achieve adequate stimulated detoxification in all organs by glutathione over the study period

Thats why real-world data can be so much faster and more representative because the data shows whats actually happening with patients in real-time and not reliant on trial enrollment