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OFarrell, Melissa A

Use of glipizide or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint

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Other key influencing factors include: Dietary habits: A calorie-controlled, nutrient-dense diet supports the medicine's effects Physical activity levels: Regular exercise enhances energy expenditure and helps preserve lean muscle mass during weight loss Genetics and individual variation: Differences in drug metabolism and receptor sensitivity may affect response