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Effect of liraglutide on the Janus kinase/signal transducer and transcription activator (JAK/STAT) pathway in diabetic kidney disease in db/db mice and in cultured endothelial cells

Furthermore, GLP-1R can also become internalized in response to GLP-1 and its analogs, indicating a complex regulatory mechanism that affects gene expression and protein activity [32]

While joint pain is not a common adverse effect of GLP-1 medications, arthralgia can occur, and any new or worsening musculoskeletal symptoms warrant appropriate clinical assessment

The GLP-1 protein is made by specific cells in the human gastrointestinal tract