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The pathophysiology behind semaglutide-induced acute pancreatitis is not fully understood, but it is hypothesized to involve alterations in pancreatic enzyme levels or direct pancreatic tissue irritation

John Wiley & Sons, Hoboken, NJ Friedli I, Baid-Agrawal S, Unwin R, Morell A, Johansson L, Hockings PD (2023) Magnetic resonance imaging in clinical trials of diabetic kidney disease

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The gastric juice origin is interesting BPC is a protein that exists naturally in the stomach, and BPC-157 is a stable synthetic fragment of that protein