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240 Furthermore, the expression of enzymes in the NAD + salvage pathway, including Nmrk1, Nampt, and Nadk, has circadian oscillation patterns in WT and Liver-RE mice that exclusively express BMAL1 in the liver, suggesting the circadian clock might reprogram NAD + salvage synthesis to maintain the fluctuation of NAD +

doi: 10.1172/JCI106507 8 BrittECLikaJGieseMASchoenTJSeimGLHuangZet al

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Unlike stealth liposomes, which rely on the enhanced permeability and retention (EPR) effect for passive accumulation in diseased tissues, active targeting liposomes are functionalized with ligands that bind selectively to overexpressed receptors on target cells