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As compared with nonobese HFpEF, patients with obesity-related HFpEF display distinct pathophysiologic features, including greater volume expansion 5,17 , more severe inflammation 6,7 , increases in visceral and paracardiac adipose tissue 5,15,18,19 and more severe myocardial injury 15

Cardiovascular Health: Studies in peer-reviewed journals such as JAMA Internal Medicine and Diabetes Care show reductions in LDL cholesterol and blood pressure, as well as a decreased risk of heart attack and stroke

Vagal innervation GI tract, liver, pancreas Autonomic innervation of adipose tissue, etc Many so called hunger and satiety hormones affect body composition independently of food intake doi.org/10.1038/s41430 2/5GLP-1 could affect metabolism (not just food intake) directly via brain or through peripheral actions

At position 34 in the amino acid chain, native GLP-1 carries a lysine residue