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Cardiovascular Considerations PT-141 can cause transient increases in blood pressure and heart rate, with mean increases of 3-10 mmHg systolic and 2-5 mmHg diastolic pressure observed in clinical trials
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Mechanistically, -ketoglutarate (KG) inhibits SIRT5-dependent desuccinylation of the PDH complex, thereby maintaining its activity and promoting OxPhos
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