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Its titration schedule is as follows: Week 1 (starting dose) : 0.6 mg per day Week 2: 1.2 mg per day Week 3: 1.8 mg per day Week 4: 2.4 mg per day Week 5 and onwards : 3 mg per day (therapeutic or maintenance dose) Rybelsus (semaglutide) daily oral dosing schedule Rybelsus comes in two formulations: R1 and R2
1 Introduction 1.1 Atherosclerosis and coronary artery disease Coronary artery disease (CAD) is a cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive ( Inflammation plays a key role in the formation of atherosclerotic plaquesthe primary pathological mechanism underlying CAD ( (IFN- ) and tumour necrosis factor (TNF)- , produced by immune cells, endothelial cells, platelets and fibroblasts are associated with atherosclerosis onset and progression
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