| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 5mg/ml | 2.0ml | 0.5mg | | 10mg/ml | 1.0ml | 1.0mg | **Best for:** Patients on 1-2mg weekly doses during titration weeks 1-8
Because insulin resistance in PCOS is a whole-body phenomenon expressed most strongly in skeletal muscle, liver, and adipose tissue, and retatrutides three signals converge on exactly those tissues indirectly, by driving large reductions in body weight and ectopic (especially hepatic) fat, and possibly directly, through incretin effects on the pancreatic islet and on adipose biology
Zhang YL, Jia SY, Yang B, Miao J, Su C, Cui ZG, Yang LM, Guo JH
These drugs were originally developed for diabetes management but have been found to also lead to significant weight loss