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The extracellular domain (ECD) is stabilised by two disulfide bonds between C50-C113 and C81C136, as in human OCT1 29 and rat OAT1 25,31

According to a study published in the BMJ, data from 9,341 obese or overweight patients treated in 37 studies with any of 18 different weight-loss drugs showed that they regained about one pound on average after stopping the drugs