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[5/6] metabolic disorders Primary hyperammonemia due to urea cycle disorders : Include: OTC, NAGS, CPS1, ArgSS, ASL, and ARG deficiencies, HHH syndrome, and type-2 citrullinemia
other trials differ) A history of unsuccessful weight loss through diet and lifestyle changes Common Reasons People Are Excluded Personal or family history of medullary thyroid carcinoma (MTC) or MEN syndrome type 2 Prior pancreatitis A type 2 diabetes diagnosis (for the obesity-only arm) Body weight change greater than 5 kg in the 90 days before screening Use of any weight-loss medication within the prior 90 days Recent cardiovascular events, which are handled differently in the cardiovascular trials If you have type 2 diabetes: Lilly has tested retatrutide in diabetes through a separate study program, but the obesity-focused TRIUMPH-1 trial excluded diabetes
These studies, which you can read about on websites like ClinicalTrials.gov, showed that 2.4 mg was the most effective dose for weight management
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