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The presence of the BLB limits delivery of active agents to the isolated microenvironment of the inner ear

In healthy cells, more than 90% of glutathione stays in its active, reduced form, ready to neutralize free radicals

This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism

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