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This liver-specific effect explains why Survodutide received FDA Breakthrough Therapy designation for MASH

The greatest changes in NCV (at 12 months) were observed in the sensory sural nerve (+5.7 m/sec in the LAC group vs +1.0 m/sec in the placebo group), sensory ulnar nerve (+2.9 vs +0.1 m/sec, respectively) and motor peroneal nerve (+2.7 vs 0.2 m/sec), whereas the greatest changes in amplitude were recorded in the motor peroneal nerve (+2.2 vs +0.1 mV)

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Both are dominated by gastrointestinal adverse events nausea, constipation, diarrhea, vomiting that are mostly mild-to-moderate and dose-related