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Liu L, Chen J, Wang L, Chen C, Chen L

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First, autophagy plays a protective role by inhibiting oxidative damage and apoptosis in CuSO 4 -induced testicular injury and spermatogenesis disruption, and second, autophagy plays an adverse role by promoting ferroptosis, thus aggravating the toxicity caused by CuSO 4 [100]

Regular clinical review should include: Assessment of weight loss trajectory and nutritional status Evaluation of fall risk, particularly in older adults Review of concomitant medications affecting bone health Monitoring for new fractures or bone pain When to seek medical advice : Patients should contact their GP if they experience unexplained bone pain, height loss, new fractures from minimal trauma, or concerns about rapid weight loss