Although prolonged treatment with oral N-acetylcysteine (NAC) prevents acute exacerbations of chronic bronchitis, it remains controversial for the treatment of COPD (91, 103105)
Subsequently, Porphyromonas and Fusobacterium exacerbated tissue necrosis by secreting proteases and keratin-degrading enzymes, ultimately inducing characteristic ulcerative lesions 138
Conversely, oxidative stress is attributed to unbridled production of ROS, surpassing the amount of antioxidant defenses and aggravating damage to cells, proteins, lipids and DNA, 18 a process which is also indicated by Fig
J Biol Chem 280:2530525312 Knollema S, Hom HW, Schirmer H, Korf J, Ter Horst GJ (1996) Immunolocalization of glutathione reductase in the murine brain