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Additionally, there was inhibition of mRNA of inflammatory mediators (iNOS, IL-6, IFN, and TNF-alpha), while BPC 157 increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GSTpi [107]
Mechanistic differences: Matrixyl acts as a matrikine -- a peptide fragment derived from extracellular matrix proteins that signals cells to increase collagen synthesis
There has been one retrospective study involving 16 patients with knee pain who were treated with BPC-157 (sometimes in combination with TB4), but its extremely limited [9]