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Total Impact: Taken together, we estimate that the changes in submissions due to policy provisions ( and newly available data will result in a change of +399 submissions (810 submissions due to policy provisions + 1,209 submissions due to updated data), an annual burden change of +3,624 hours (7,357.23 hr due to policy provisions + 10,981.35 hr due to updated data, rounded to the hour) at a cost of +$444,109 ($901,575.18 due to policy provisions + $1,345,684.44 due to updated data, rounded to the dollar)

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Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening: A multicountry patient-level meta-analysis of 141,220 screened individuals