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In 2004, Jeffrey Gordon and colleagues initially documented a notable disparity in body fat content between germ-free mice and conventionally raised mice with normal GM, with the latter exhibiting 40% greater body fat (129)

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It is the case that ZagA binds and hydrolyzes the alarmone, 5-amino 4-imidazole carboxamide riboside 5-triphosphate (ZTP), which accumulates in cells under 1C folate deficiency, 198 the functional significance of which is remains unknown