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It is well known that cancer development and treatment can be affected by genetic factors, epigenetic modifiers, CSCs, and the TME (Xiang et al., 2019)

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Sci Transl Med 7:308re8 Lee JS, Kim E, Lee J, Kim D, Kim H, Kim CJ et al (2020) Capicua suppresses colorectal cancer progression via repression of ETV4 expression