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Timing your first dose should account for several practical factors: Dietary planning : Consider starting when you can maintain a regular eating pattern and have access to light, easily digestible meals, as gastrointestinal side effects are most common initially Monitoring capability : Choose a time when you can observe your body's response and have access to medical advice if needed Social calendar : Avoid starting immediately before important events, travel, or periods of high stress Support availability : Begin when family members or carers are available to assist if you experience side effects Dose escalation protocols are standard with GLP-1 therapy to minimise adverse effects

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It is commonly used to treat major depressive disorder (MDD) and to treat and prevent seasonal affective disorder (SAD)

Statements Author contributions ZQ: Writing original draft, Conceptualization