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Current Opinion in Psychiatry, 25 (1), 10-15

Clinical evidence suggests that these medications have neurobiological activity, including protection against neuronal degeneration and inflammation, as well as modulation of dopamine-related reward mechanisms, the researchers write in the study paper

A post-hoc analysis of the STEP clinical trials found that people taking antidepressants lost comparable amounts of weight on semaglutide to those not taking antidepressants