Other common side effects include: Reduced appetite Constipation Diarrhoea Bloating Fatigue Mild headaches Most of these effects improve within the first few weeks
In addition to the ending of the menstrual cycle, menopause may bring a variety of symptoms, including hot flashes, mood swings, fatigue, sleeping difficulties, and weight gain
Injection burden 1-2 injections per day on overlap days Best for Metabolic + mitochondrial pairing Cycle driver Retatrutide titration sets the pace Retatrutide Loading 1 2 4 6 9 mg (every 4 weeks) Frequency Once weekly Maintenance 9 mg or 12 mg weekly Route SubQ MOTS-c (intermittent - most common) Loading Start Week 5: 5 mg, 2x weekly Frequency 2-3x weekly Maintenance 5-10 mg, 2-3x weekly Route SubQ MOTS-c (low-dose daily - alternative) Loading Start Week 5: 200 mcg/day, +200 mcg every 2 weeks Frequency Daily Maintenance Up to 1 mg daily Route SubQ Weekly Schedule Example - Intermittent MOTS-c (Weeks 5-16) Monday Retatrutide 2 mg (morning) + MOTS-c 5 mg (pre-training) Tuesday Rest day Wednesday MOTS-c 5 mg (pre-training) Thursday Rest day Friday MOTS-c 5 mg (pre-training) Saturday Rest day Sunday Rest day Community protocols use different injection sites and separate syringes when both compounds are dosed the same day
Planning around Zepbounds elimination timeline helps you navigate treatment interruptions, manage expectations about appetite changes, and prepare for life after medication
