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In the context of FPN deficiency or inadequate expression, the cells cannot efficiently export iron, resulting in continued accumulation of free iron and further enhancing the detrimental effects of ferroptosis

Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)

PALMITOYL-ETHANOL-AMIDE (PEA) Inclusion: Known for its anti-inflammatory and analgesic properties, PEA adds to the supplement's effectiveness