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Research suggests that semaglutide, on insulin signaling, might disrupt the regulation of the HPA axis, neurotrophic factors, and neurotransmitters involved in depression and other mental health conditions

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Serious side effects, such as signs of heart problems or severe mood changes, require immediate medical attention

Your complete medical history should be reviewed, including: Cardiovascular conditions (hypertension, arrhythmias, heart disease) History of eating disorders or significant weight fluctuations Mental health conditions (anxiety, depression, bipolar disorder) Gastrointestinal disorders (gastroparesis, inflammatory bowel disease) Diabetes and current glucose-lowering medications Any history of substance misuse Gallbladder disease or pancreatitis Pregnancy and contraception must be discussed