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The primary purpose was to determine the safety and efficacy of ARA 290 on metabolic control and neuropathic symptoms in subjects with type 2 diabetes

In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]

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