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In contrast, improvement in the inflammatory process can be judged by improvements in the levels of markers such as neutrophils, macrophages, lymphocytes, eosinophils, CRP, TNF-, IL-6 or changes in the production and expression of reactive oxygen species (ROS), and the clinical benefit that may be gained from these changes should be reflected in improvements in the final effects of chronic inflammation

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CRISPR gene editing, isotope tracing, and gnotobiotic mouse colonization were used to mechanistically interrogate the identified genes