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Dtsch Arztebl Int 2020;117(24):412-9 Benkert O, Hippius H

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Glucose deprivation reduces the PPP-mediated NADPH generation, making it impossible to reduce insoluble cystine imported via xCT to a more soluble cysteine, thereby inducing disulfide stress (i.e., cystine-dependent toxicity) and leading to rapid cell death [48] [Figure 3B]