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Hypoxic kidney organoids treated with SGLT2i confirmed these protective effects

doi: 10.1530/ERC-17-0253 42 DalJFeldt-RasmussenUAndersenMKristensenLOLaurbergPPedersenLet al

The medication does not appear to lose effectiveness over extended periods, which distinguishes it from many previous weight management approaches that showed diminishing returns

Rather than acting on fat directly, it stimulates the pituitary gland to release growth hormone in a natural, pulsatile pattern, which raises insulin-like growth factor-1 (IGF-1) and increases lipolysis, or the breakdown of stored fat, with a documented preference for visceral rather than subcutaneous tissue